MedlinePlus: Low Folate Levels May Harm = Sperm

Low Folate Levels May Harm Sperm

Prospective=20 dads might want to up their intake of the nutrient, study = suggests=20

HealthDay

Thursday, March 20, 2008 =

3D"HealthDay WEDNESDAY,=20 March 19 (HealthDay News) -- The benefits of folate for women in = preventing=20 birth defects are well known, but new research suggests the nutrient = also boosts=20 sperm health.

Men with relatively low levels of folate had increased risks for = sperm=20 containing either too few or too many chromosomes, according to = researchers at=20 the University of California, Berkeley. These types of deficiencies can = cause=20 birth defects and miscarriages, the experts noted.

Folate is one of the B vitamins and is found in leafy green = vegetables, fruit=20 and beans, chickpeas and lentils. By law, breads and grains sold in the = United=20 States are also now specially fortified with added folate to help ward = off birth=20 defects.

"We looked at sperm to find different kinds of genetic = abnormalities," said=20 lead researcher Brenda Eskenazi, a professor of maternal and child = health and=20 epidemiology and director of the Center for Children's Environmental = Health at=20 Berkeley's School of Public Health. "The abnormalities we looked at here = were=20 having too few or too many chromosomes," she said.

Normally, human sperm have 23 pairs of chromosomes. "In sperm you = normally=20 have one of each, but sometimes there are two and sometimes there are = none of a=20 particular chromosome," Eskenazi said.

If a normal egg was fertilized with one of these abnormal sperm, it = could=20 result in a birth defect, such as Down's syndrome, Eskenazi said. "This = can also=20 result in an increase in miscarriage," she said.

The researchers looked at three specific chromosomes: X, Y and 21. = "We saw an=20 association between [male] folate intake and how many abnormal sperm = there were,=20 in terms of the chromosome number for these three different = chromosomes,"=20 Eskenazi said.

The study findings are published in the March 20 issue of the journal = Human Reproduction.

In the study, Eskenazi's group analyzed sperm from 89 healthy men. In = addition, the researchers asked the men about their daily consumption of = zinc,=20 folate, vitamin C, vitamin E and beta-carotene.

The researchers found that men who had the highest intake of folate = had the=20 lowest incidence of sperm abnormalities. In fact, men who had the = highest intake=20 of folate -- 722 to 1,150 micrograms a day -- had a 20 percent to 30 = percent=20 lower frequency of several types of sperm abnormalities, compared with = men who=20 consumed less folate.

Up till now, birth-defect researchers have typically focused on = women's diet=20 in the period around conception, Eskenazi said. "Based on these data, = maybe men,=20 too, need to consider their diet when they are considering fathering a = child,"=20 she said.

Although this study doesn't conclusively prove a link between folate = and=20 chromosomal abnormality, Eskenazi advises men who are thinking of = becoming=20 fathers to increase their folate intake, perhaps with a supplement or a=20 multivitamin containing folate.

This isn't the first study to find a link between diet and sperm = health. A=20 report published last year in Human Reproduction found that women = who ate=20 beef seven or more times per week tended to produce sons with lowered = sperm=20 counts, perhaps due to the effects of hormones or pesticides on = developing=20 testes.

One expert agrees that healthy eating is linked to having healthy = babies --=20 even for men.

"This is another common-sense article that says good nutrition is = associated=20 with a better reproductive outcome," said Dr. Jamie Grifo, director of=20 reproductive endocrinology at New York University Medical Center.

Grifo noted that rates of abnormal sperm seen in the Berkeley study = were four=20 to six per 1,000, which means that men with poor nutrition still had = more than=20 99 percent normal sperm.

"Even though this may be the case, don't smoke, drink modestly, eat = healthy=20 unprocessed food and take your vitamins," Grifo advised prospective = fathers.=20

More = News on=20 this Date

Related MedlinePlus Pages:

Birth=20 Defects=20
Folic = Acid=20

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Copyright = \|=20 Privacy \| = Accessibil= ity=20 \| Quality=20 Guidelines U.S. National = Library of=20 Medicine, 8600 Rockville Pike, Bethesda, MD 20894 National = Institutes of=20 Health \| Department of = Health &=20 Human Services	Date last updated: 20 March 2008=20

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inline; PADDING-LEFT: 0.55em; = FONT-WEIGHT: bold; FONT-SIZE: 0.68em; PADDING-BOTTOM: 0px; PADDING-TOP: = 0px } .alist LI.last { MARGIN-LEFT: 15px } DIV.bodymaps { CLEAR: both; MIN-WIDTH: 780px; MAX-WIDTH: 1024px; MARGIN-LEFT: auto; ; = WIDTH: expression(document.body.clientWidth < 780 ? "780px" : "100%" ); = MARGIN-RIGHT: auto } .newflag { VERTICAL-ALIGN: -10%; MARGIN-RIGHT: 6px; BACKGROUND-COLOR: transparent } .orgs { PADDING-LEFT: 4px } .bulletlist_nomargin { LIST-STYLE-POSITION: outside; LIST-STYLE-TYPE: disc } .bulletlist_nomargin LI { PADDING-LEFT: 0px; LINE-HEIGHT: 130% } .bulletlist_nomargin LI IMG { VERTICAL-ALIGN: text-bottom } #flashcontent { FONT-WEIGHT: bold; FONT-FAMILY: Arial, Helvetica, sans-serif; = TEXT-ALIGN: center } #flashcontent P { PADDING-RIGHT: 0px; BACKGROUND-POSITION: center 50%; PADDING-LEFT: 0px; = PADDING-BOTTOM: 6px; MARGIN: 0px; PADDING-TOP: 6px; BACKGROUND-REPEAT: = no-repeat } #flashcontent P.link A { PADDING-RIGHT: 0px; BACKGROUND-POSITION: center 50%; PADDING-LEFT: = 169px; PADDING-BOTTOM: 6px; MARGIN: 0px; PADDING-TOP: 6px; = BACKGROUND-REPEAT: no-repeat } #flashcontent P.link { BACKGROUND-IMAGE: url(get_flash_player.gif) } #flashcontent P.link A:hover { BACKGROUND-IMAGE: url(get_flash_player.gif) } .nlbox { BACKGROUND: url(new_bl.gif) rgb(255,208,66) no-repeat left bottom } .nlbox-outer { BACKGROUND: url(new_br.gif) no-repeat right bottom } .nlbox-inner { BACKGROUND: url(new_tl.gif) no-repeat left top } .nlr { BACKGROUND: url(new_tr.gif) no-repeat right top } .nlbox P { MARGIN-TOP: 0px; MARGIN-BOTTOM: 2px; PADDING-BOTTOM: 5px; MARGIN-LEFT: = 2px } .imgdesc { MARGIN-LEFT: 4px; VERTICAL-ALIGN: -10% } .pricontent { FLOAT: left; WIDTH: 100%; MARGIN-RIGHT: -320px; voice-family: inherit } .pricontent #innercontent { MARGIN-RIGHT: 320px; PADDING-TOP: 0px; voice-family: inherit } .seccontent { PADDING-RIGHT: 0px; MARGIN-TOP: 0px; PADDING-LEFT: 5px; FLOAT: right; = PADDING-BOTTOM: 0px; PADDING-TOP: 0px; voice-family: inherit } ------=_NextPart_000_0000_01C8A455.04DC48E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nlm.nih.gov/medlineplus/images/advanced.css HTML { MARGIN-TOP: 0px } BODY { MARGIN-TOP: 0px } LI.title { FONT-SIZE: 120% } UL.topicGroup { MARGIN-TOP: 0px; PADDING-LEFT: 0px; MARGIN-LEFT: 1.2em } #tutorial_list { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px } #tutorial_list LI.section { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; FLOAT: left; PADDING-BOTTOM: = 0px; MARGIN: 0px 0px 20px; WIDTH: 47%; PADDING-TOP: 0px; = LIST-STYLE-TYPE: none } #tutorial_list UL { PADDING-RIGHT: 0px; PADDING-LEFT: 25px; FONT-SIZE: 83%; PADDING-BOTTOM: = 0px; MARGIN: 0px; PADDING-TOP: 5px; LIST-STYLE-TYPE: none } #tutorial_list UL LI { BACKGROUND-POSITION: left center; PADDING-LEFT: 15px; BACKGROUND-IMAGE: = url(http://www.nlm.nih.gov/images/bullet.gif); WIDTH: 100%; = BACKGROUND-REPEAT: no-repeat } .listSpace { MARGIN-BOTTOM: 2em } ------=_NextPart_000_0000_01C8A455.04DC48E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nlm.nih.gov/medlineplus/images/header.css #toptable { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; WIDTH: = 100%; PADDING-TOP: 0px; BORDER-COLLAPSE: collapse } #toptable TH { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #toptable TD { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; = PADDING-TOP: 0px } #toptable TD { TEXT-ALIGN: left } #topcontainer { PADDING-RIGHT: 0px; PADDING-LEFT: 0px; PADDING-BOTTOM: 0px; MARGIN: = 0px; PADDING-TOP: 0px; BORDER-BOTTOM: #330066 1px solid; HEIGHT: 26px; = BACKGROUND-COLOR: #fffaea } #topcontainer IMG { BORDER-RIGHT: medium none; PADDING-RIGHT: 0px; BORDER-TOP: medium none; = PADDING-LEFT: 0px; FLOAT: right; PADDING-BOTTOM: 0px; BORDER-LEFT: = medium none; PADDING-TOP: 0px; BORDER-BOTTOM: medium none } #searchform { FLOAT: left; MARGIN: 1px 0px 0px; WIDTH: 320px } #mainmenu { PADDING-TOP: 0px } #mainmenu A { DISPLAY: block; FLOAT: left; COLOR: #000; LINE-HEIGHT: 22px; HEIGHT: = 22px; TEXT-DECORATION: none } A:link { COLOR: #660099 } A:visited { COLOR: #660000 } A:hover { COLOR: red } A:active { COLOR: #660000 } #skipnav { FONT-SIZE: 65% } ------=_NextPart_000_0000_01C8A455.04DC48E0 Content-Type: text/css; charset="iso-8859-1" Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nlm.nih.gov/medlineplus/images/menubutton.css #tab0 { BACKGROUND: url(tabhome.gif) #000 no-repeat left top; WIDTH: 41px; = HEIGHT: 22px } #tab0:hover { BACKGROUND: url(tabhome.gif) #000 no-repeat right top } #tab21 { BACKGROUND: url(tabhealthtopics.gif) #000 no-repeat left top; WIDTH: = 86px } #tab21:hover { BACKGROUND: url(tabhealthtopics.gif) #000 no-repeat right top } #stab21 { BACKGROUND: url(tabhealthtopics.gif) #000 no-repeat right top; WIDTH: = 86px } #stab21:hover { BACKGROUND: url(tabhealthtopics.gif) #000 no-repeat right top; CURSOR: = default } #tab20 { BACKGROUND: url(tabdrug.gif) #000 no-repeat left top; WIDTH: 135px } #tab20:hover { BACKGROUND: url(tabdrug.gif) #000 no-repeat right top } #stab20 { BACKGROUND: url(tabdrug.gif) #000 no-repeat right top; WIDTH: 135px } #stab20:hover { BACKGROUND: url(tabdrug.gif) #000 no-repeat right top; CURSOR: default } #tab33 { BACKGROUND: url(tabency.gif) #000 no-repeat left top; WIDTH: 87px } #tab33:hover { BACKGROUND: url(tabency.gif) #000 no-repeat right top } #stab33 { BACKGROUND: url(tabency.gif) #000 no-repeat right top; WIDTH: 87px } #stab33:hover { BACKGROUND: url(tabency.gif) #000 no-repeat right top; CURSOR: default } #tab1 { BACKGROUND: url(tabdictionaries.gif) #000 no-repeat left top; WIDTH: = 66px } #tab1:hover { BACKGROUND: url(tabdictionaries.gif) #000 no-repeat right top } #stab1 { BACKGROUND: url(tabdictionaries.gif) #000 no-repeat right top; WIDTH: = 66px } #stab1:hover { BACKGROUND: url(tabdictionaries.gif) #000 no-repeat right top; CURSOR: = default } #tab38 { BACKGROUND: url(tabnews.gif) #000 no-repeat left top; WIDTH: 41px } #tab38:hover { BACKGROUND: url(tabnews.gif) #000 no-repeat right top } #stab38 { BACKGROUND: url(tabnews.gif) #000 no-repeat right top; WIDTH: 41px } #stab38:hover { BACKGROUND: url(tabnews.gif) #000 no-repeat right top; CURSOR: default } #tab11 { BACKGROUND: url(tabdirectories.gif) #000 no-repeat left top; WIDTH: = 71px } #tab11:hover { BACKGROUND: url(tabdirectories.gif) #000 no-repeat right top } #stab11 { BACKGROUND: url(tabdirectories.gif) #000 no-repeat right top; WIDTH: = 71px } #stab11:hover { BACKGROUND: url(tabdirectories.gif) #000 no-repeat right top; CURSOR: = default } #tab22 { BACKGROUND: url(tabother.gif) #000 no-repeat left top; WIDTH: 106px } #tab22:hover { BACKGROUND: url(tabother.gif) #000 no-repeat right top } #stab22 { BACKGROUND: url(tabother.gif) #000 no-repeat right top; WIDTH: 106px } #stab22:hover { BACKGROUND: url(tabother.gif) #000 no-repeat right top; CURSOR: default } ------=_NextPart_000_0000_01C8A455.04DC48E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nlm.nih.gov/medlineplus/images/static.js // MedlinePlus General Purpose JavaScript Library=0A= //=0A= //Purpose: Central repository for javascript functions for both the = MedlinePlus Application=0A= //and Static Site. Functions which are exclusively used by the = application belong in dynamic.js=0A= function include(file) {=0A= var script =3D document.createElement('script');=0A= script.src =3D file;=0A= script.type =3D 'text/javascript';=0A= script.defer =3D true;=0A= =0A= var node =3D document.getElementsByTagName('head').item(0);=0A= node.appendChild(script);=0A= }=0A= =0A= //frame breaking script=0A= var notGovSite =3D document.referrer.indexOf('.gov/') < 0;=0A= =0A= // Allow www.ala.org and www.zhost.com base on LO's request. 02/28/2008 = Ta-Sun =0A= var notalaorg =3D document.referrer.indexOf('www.ala.org/') < 0;=0A= var notzhostcom=3D document.referrer.indexOf('www.zhost.com/') < 0;=0A= =0A= var trackingImg =3D = "http://wwwdev.nlm.nih.gov/results/medlineplus/leavemplus.html?";=0A= if (top.location !=3D self.location && notGovSite && notalaorg && = notzhostcom){=0A= location.replace('http://www.nlm.nih.gov/medlineplus/framing.html');=0A= }=0A= =0A= =0A= buttonStates=3Dnew Object;=0A= if (undefined =3D=3D imageNames) {=0A= imageNames =3D false;=0A= }=0A= if (document.images && imageNames) {=0A= for(var button in imageNames)=0A= {=0A= =0A= buttonStates[button+"On"]=3D new Image();=0A= buttonStates[button+"Off"]=3D new Image();=0A= buttonStates[button+"On"].src=3D imagePath + "/" + button + = "_button2" + langExt + ".gif";=0A= buttonStates[button+"Off"].src=3D imagePath + "/" + button + = "_button1" + langExt + ".gif";=0A= =0A= }=0A= =0A= }=0A= =0A= function depress(thisImg) {=0A= if (document.images) {=0A= //alert(buttonStates[(thisImg + "On")].src);=0A= imgOn =3D (buttonStates[(thisImg + "On")].src);=0A= document.imgForm [thisImg].src =3D imgOn;=0A= }=0A= }=0A= =0A= function unpress(thisImg) {=0A= if (document.images) {=0A= imgOff =3D (buttonStates[(thisImg + "Off")].src);=0A= document.imgForm [thisImg].src =3D imgOff;=0A= }=0A= }=0A= =0A= =0A= =0A= var isW3C =3D (document.getElementById) ? true : false;=0A= var isAll =3D (document.all) ? true : false;=0A= var isOperaMac =3D (navigator.userAgent.indexOf('Opera') !=3D -1 && = navigator.platform.indexOf('MacPPC') !=3D -1 ) ? true : false;=0A= var HSCALE=3D0.9; //default percentage to scale popup windows = horizontally=0A= var VSCALE=3D0.9; //default percentage to scale popup windows vertically=0A= =0A= //=0A= //function centeredPopup(url, name, noChrome, width, height)=0A= //Description: Replacement for three previous js functions opens a named = popup window=0A= // url - string, required, relative or full url to the html which will = populate the new window=0A= // name - string, optional, the name of this new popup window - = default=3D"theNewWin"=0A= // noChrome - boolean, optional, the newly created window will have all = or no features - default=3D"false"=0A= // width - number/int, optional, the width of the desired popup - = default=3Dpercentage (based on const HSCALE) of parent window width=0A= // height - number/int, optional, the height of the desired popup - = default=3Dnone, allow the client system to manage the height of the popup=0A= //Usage:=0A= //Click=0A= //=0A= function centeredPopup(url, name, noChrome, width, height)=0A= {=0A= var features;=0A= var popupDimensions=3DdefaultPopupDims(); //obj holds the default = popuDimensions, based on Parent Window=0A= =0A= //availheight and width mostly for Opera interoperability=0A= var myAvailWidth=3DgetAvailWidth();=0A= var myAvailHeight=3DgetAvailHeight();=0A= =0A= if( url )=0A= {=0A= //handle calls using the old Mplus popup window javascript=0A= if(url=3D=3D"#")=0A= {=0A= url=3D'';=0A= }=0A= =0A= if(!name)=0A= {=0A= name=3D"TheNewWin";=0A= }=0A= =0A= //ensure width bounds checking, if it doesn't have a value, give it = the default=0A= if( isNaN(width) )=0A= {=0A= width=3DpopupDimensions.width;=0A= }=0A= =0A= if(width > myAvailWidth || width < 0)=0A= {=0A= width=3DparseInt(myAvailWidth * HSCALE);=0A= }=0A= =0A= //check whether this will be a chromeless window=0A= if( noChrome =3D=3D true=0A= || noChrome =3D=3D "true"=0A= || noChrome =3D=3D "True"=0A= )=0A= {=0A= //alert("(" + noChrome + ")");=0A= = features=3D'toolbar=3Dno,location=3Dno,status=3Dno,menubar=3Dno,scrollbar= s=3Dyes,resizable=3Dyes,width=3D' + width + ',';=0A= }=0A= else=0A= {=0A= = features=3D'toolbar=3Dyes,location=3Dyes,status=3Dyes,menubar=3Dyes,scrol= lbars=3Dyes,resizable=3Dyes,width=3D' + width+ ',';=0A= }=0A= =0A= //if height wasn't defined get default=0A= //note: default height for IE will be 0, IE doesn't give us = sufficient info=0A= //to calculate parent window dimensions=0A= if(!height)=0A= {=0A= height=3DpopupDimensions.height;=0A= //alert(height);=0A= }=0A= =0A= //check the height attrib, ensure it doesn't exceed viewable real = estate=0A= //if so, the reduce it to VSCALE set by script designer.=0A= if(height > myAvailHeight || height < 1)=0A= {=0A= height=3DparseInt(myAvailHeight * VSCALE -100)=0A= }=0A= else=0A= {=0A= //Opera 6.x Macintosh PPC requires a height value when rendering a = new window (if you specify width)=0A= if( isOperaMac )=0A= {=0A= //alert("detected Macintosh Opera!");=0A= height=3DparseInt(myAvailHeight *VSCALE);=0A= }=0A= }=0A= =0A= =0A= features+=3D'height=3D'+height+',';=0A= features +=3D = getCenteredCoords(myAvailWidth,myAvailHeight,width,height);=0A= //alert("Features: " + features);=0A= =0A= popUpWin =3D window.open(url, name, features);=0A= =0A= if( window.focus && !isOperaMac)=0A= {=0A= popUpWin.focus();=0A= }=0A= return false;=0A= }=0A= return true;=0A= }=0A= =0A= //workaround for Opera in MDI mode, must calc the "real" availWidth.=0A= function getAvailWidth()=0A= {=0A= var myWidth=3Dscreen.availWidth;=0A= =0A= if(self.screenX && self.screenLeft && (self.screenX !=3D = self.screenLeft) )=0A= {=0A= myWidth =3D myWidth - self.screenLeft + self.screenX;=0A= }=0A= =0A= return myWidth;=0A= }=0A= =0A= function getAvailHeight()=0A= {=0A= var myHeight=3Dscreen.availHeight;=0A= =0A= if(self.screenY && self.screenTop && (self.screenY !=3D = self.screenTop) )=0A= {=0A= myHeight =3D myHeight - (self.screenTop - self.screenY);=0A= }=0A= //alert("myHeight: " + myHeight);=0A= return myHeight;=0A= }=0A= =0A= =0A= =0A= function getCenteredCoords(myAvailWidth, myAvailHeight, width, height)=0A= {=0A= var coords=3D"";=0A= var top, left;=0A= =0A= if(width)=0A= {=0A= left=3DparseInt(.5 * (myAvailWidth - width) );=0A= if(left < 0)=0A= left=3D0;=0A= coords+=3D'left=3D'+left+',screenX=3D'+left;=0A= =0A= //calculate the centered position for height only if we have a value = for it=0A= if(height)=0A= {=0A= =0A= top=3DparseInt(0.5* (myAvailHeight - height) - 50);=0A= if(top < 0)=0A= top=3D0;=0A= coords +=3D ',top=3D'+top+',screenY=3D'+top;=0A= }=0A= =0A= //alert("Coordinates: " + coords);=0A= return coords;=0A= }=0A= return;=0A= }=0A= =0A= //function defaultPopupDims()=0A= //Description: Helper Function for centeredPopup(), called when user = doesn't specify=0A= // a width and height for the new window.=0A= //In: Nothing=0A= //Out: dimensions in object form obj.width=3Dwidth, obj.height=3Dheight=0A= =0A= function defaultPopupDims()=0A= {=0A= //first set an absolute fallback value, in case the object sniffing = breaks due to weird=0A= //browsers=0A= var dims =3D new Object();=0A= dims.width =3D 700;=0A= dims.height =3D 700;=0A= =0A= //work out the width and height of Netscape 4.x, Mozilla, & Opera 7.x = Browser=0A= if( !isNaN( window.innerWidth) && window.innerWidth > 0 )=0A= {=0A= //Non-IE browsers e.g. Netscape, Opera, Safari, etc.=0A= dims.width =3D parseInt(window.innerWidth * HSCALE);=0A= dims.height =3D parseInt(window.innerHeight * VSCALE);=0A= //alert('for netscape 4 mozilla and opera');=0A= }=0A= else=0A= {=0A= if( document.documentElement && document.documentElement.offsetWidth = )=0A= {=0A= //IE 6+, and any IE Compatible Browsers that supports the = documentElement properties=0A= dims.width =3D parseInt(document.documentElement.offsetWidth * = HSCALE);=0A= dims.height =3D parseInt(document.documentElement.offsetHeight * = VSCALE);=0A= //alert('for ie 6+ and any ie compatible browser support = documentelement properties');=0A= =0A= }=0A= else=0A= {=0A= if( document.body && document.body.offsetWidth)=0A= {=0A= //IE 4 and above compatible=0A= dims.width =3D parseInt(document.body.offsetWidth * HSCALE);=0A= dims.height =3D parseInt(document.body.offsetHeight * VSCALE);=0A= //alert('ie 4 and above ');=0A= =0A= }=0A= }=0A= }=0A= =0A= if (dims.width =3D=3D undefined || dims.height =3D=3D undefined ||=0A= isNaN(dims.width) || isNaN(dims.height))=0A= {=0A= dims.width =3D 700;=0A= dims.height =3D 700;=0A= //alert('dims.width is '+dims.width+' dims.height is '+dims.height);=0A= }=0A= =0A= return dims;=0A= }=0A= =0A= =0A= //these functions are deprecated, they are here to ensure nothing breaks = during the transition=0A= //after all instances have been removed in the code, they will be = removed.=0A= function openOutWin(url)=0A= {=0A= //=0A= if(!url)=0A= url=3D'#';=0A= centeredPopup(url, 'TheNewWin');=0A= return true;=0A= =0A= }=0A= =0A= function openNewWin(windowName)=0A= {=0A= centeredPopup('#', windowName);=0A= return true;=0A= }=0A= =0A= function openNamedOutWin(url, name) {=0A= centeredPopup(url,name, true, 750);=0A= }=0A= =0A= function openNakedWin(windowName)=0A= {=0A= centeredPopup('#', windowName, true);=0A= return true;=0A= }=0A= =0A= function orLivePopup(url){=0A= centeredPopup(url, "orLive", true, 780, 460);=0A= return true;=0A= }=0A= =0A= //end deprecated functions=0A= =0A= function isEmpty(inputStr) {=0A= for(var i=3D0; i{errMsg}";=0A= if(myForm.subject.value !=3D "" && myForm.message2.value !=3D "")=0A= {=0A= //The user has filled out the required fields, continue = submission.=0A= =0A= //if a state has been selected, deselect the country=0A= if ( myForm.state[0].selected =3D=3D false )=0A= {=0A= myForm.country[0].selected =3D true;=0A= }=0A= //now we return true to allow the form submission=0A= return true;=0A= }=0A= else=0A= {=0A= //user forgot to fill in one of the required fields=0A= alert(errMsg);=0A= //cancel submit=0A= return false;=0A= }=0A= }=0A= =0A= image1 =3D new Image(); image2 =3D new Image(); image3 =3D new Image(); = image4 =3D new Image(); image5 =3D new Image(); image6 =3D new Image(); = image7 =3D new Image();=0A= =0A= =0A= //cit script for opening a popup window for a videocast=0A= function iwin(_url,_w,_h) {=0A= window.open(_url,"_accordent","width=3D"+ _w +",height=3D"+ _h = +",resizable=3Dno,scrollbars=3Dno,status=3Dyes",true);=0A= }=0A= =0A= //use for the goLocal Box on Mplus topic pages, merely decides whether = or not to open the FoLocal Url in a popup or not.=0A= =0A= function goLocalPage(url){=0A= if(url)=0A= {=0A= //if the site is hosted, go there else pop open window=0A= if (url.indexOf('nlm.nih.gov') > 0)=0A= location.href=3Durl;=0A= else=0A= {=0A= openOutWin(url);=0A= }=0A= }=0A= return false;=0A= }=0A= =0A= =0A= function AddListDividers(container_id,interval) {=0A= =0A= if(document.getElementById) {=0A= =0A= var container =3D document.getElementById(container_id);=0A= var listitems =3D container.getElementsByTagName("li");=0A= =0A= var adjusteditems =3D new Array(listitems.length);=0A= =0A= for(var i=3D0; i=0A= //Arguments:=0A= // - String: name of the ID of the list that is to be modified=0A= // - Integer: frequency of the spacing (Optional)=0A= function listSpacing(listID, frequency) {=0A= var list=3Ddocument.getElementById(listID).childNodes; //list is now = equal to the array of child nodes=0A= var listNodeCounter=3D1;=0A= if(! isDefined(frequency)){=0A= frequency=3D5;=0A= }=0A= for (var h =3D 0; h < list.length; h++) {=0A= if(list[h].nodeType =3D=3D1){ //ensure the child node is = an actual element, not whitespace or text=0A= if(listNodeCounter % frequency =3D=3D 0){=0A= list[h].className=3D"listSpace";=0A= }=0A= listNodeCounter =3D listNodeCounter +1;=0A= }=0A= =0A= }=0A= return;=0A= }=0A= =0A= //library function to mimic the isDefined functionality of higher level = languages=0A= // returns true if variable passed is defined, false otherwise=0A= function isDefined(testArgument){=0A= if(typeof testArgument =3D=3D 'undefined'){=0A= return false;=0A= }=0A= return true;=0A= }=0A= =0A= //Created for printing flash movie scrollable text area contents. Using = fscommand to pass flash contents to new window.-- Jeff Bao=0A= function windowPrint(args) {=0A= var myAvailWidth=3DgetAvailWidth();=0A= var myAvailHeight=3DgetAvailHeight();=0A= var features;=0A= var msgWindow;=0A= var csspath=3D'';=0A= var popupDimensions=3DdefaultPopupDims(); //obj holds the default = popuDimensions, based on Parent Window=0A= height=3DpopupDimensions.height;=0A= width=3DpopupDimensions.width;=0A= = features=3D'toolbar=3Dno,location=3Dno,status=3Dno,menubar=3Dno,scrollbar= s=3Dyes,resizable=3Dyes,width=3D' + width + ',height=3D' + height;=0A= features +=3D = getCenteredCoords(myAvailWidth,myAvailHeight,width,height);=0A= msgWindow=3Dwindow.open("","PrintWindow",features)=0A= msgWindow.document.open()=0A= msgWindow.document.write("MedlinePlus Print Message = Window<\/title><\/head>")=0A= msgWindow.document.write(csspath+args)=0A= msgWindow.document.close()=0A= msgWindow.focus()=0A= }=0A= function leavemplus(param1, param2) {=0A= var img =3D document.createElement("img");=0A= img.setAttribute("src",trackingImg + param1);=0A= //alert(trackingImg + param1);=0A= }=0A= =0A= include('http://www.nlm.nih.gov/medlineplus/images/trace.js');=0A= ------=_NextPart_000_0000_01C8A455.04DC48E0 Content-Type: application/octet-stream Content-Transfer-Encoding: quoted-printable Content-Location: http://www.nlm.nih.gov/medlineplus/images/mplus_en_survey.js // ****************************** // * triggerParams.js * // ****************************** // Customer: National Library of Medicine // Version : DHTML Trigger 2.4 function cppUrlPatch(s) { var translated =3D ""; var i;=20 var found =3D 0; for(i =3D 0; (found =3D s.indexOf(':', found)) !=3D -1; ) { translated +=3D s.substring(i, found) + "|"; i =3D found + 1; found++; } translated +=3D s.substring(i, s.length); return translated; } var triggerParms =3D new Array();=20 var excludeList =3D new Array(); triggerParms["dt"] =3D 0; // disable trigger if 1 triggerParms["mid"] =3D "p18ExFQhQFBBJk91MVxBFQ=3D=3D"; // model = instance id triggerParms["cid"] =3D "WyHFr2m0PoaGCBUsi00QIQ=3D=3D"; // customer id triggerParms["lf"] =3D 3; // loyalty factor triggerParms["sp"] =3D 0.4; // sample percentage triggerParms["npc"] =3D 0; // no persistent cookies if 1 triggerParms["rw"] =3D 43200; // resample wait (value in minutes) triggerParms["pu"] =3D 0; // pop-under control triggerParms["olpu"] =3D 1; // On Load pop-under control triggerParms["lfcookie"] =3D "ForeseeLoyalty_MID_p18ExFQhQF"; triggerParms["ascookie"] =3D "ForeseeSurveyShown_p18ExFQhQF"; triggerParms["width"] =3D 420; // survey width triggerParms["height"] =3D 500; // survey height triggerParms["domain"] =3D ".nih.gov"; // domain name triggerParms["omb"] =3D "1505-0186"; // OMB number //triggerParms["cmetrics"] =3D "90010257"; // coremetrics client id triggerParms["cpp_1"] =3D "userURL:" + cppUrlPatch = (window.location.href); triggerParms["cpp_2"] =3D "Browser:"+ cppUrlPatch (navigator.userAgent); = // customer parameter 2 - Browser triggerParms["capturePageView"] =3D 1; //excludeList[0] =3D "/exclude/"; //trigger script will not work under = this path //triggerParms["dcUniqueId"] =3D "TEST04JloZZN0k9cI1Ep5d"; // (22 chars = unique Id for double cookie I/II) //triggerParms["midexp"] =3D 129600; // model instance expiry value triggerParms["rso"]=3D 0; //user has chosen to use Retry Survey Option triggerParms["aro"]=3D 0; //user has chosen to use Auto Retry Option, = with SP=3D100 //triggerParms["rct"]=3D 1; //The maximum number of times allowed to = serve a survey to a user //triggerParms["rds"]=3D 1; //The minimum number of days to wait to = serve a survey repeatedly //triggerParms["mrd"]=3D 1; //The total number of days that a user can = be re-served a survey triggerParms["compliant508"] =3D 0; //508 compliant if 1 //DHTML Parameter triggerParms["dhtml"]=3D 1;// disable dhtml trigger if dhtml=3D0 triggerParms["dhtmlWidth"] =3D 400; // welcome page width triggerParms["dhtmlHeight"] =3D 290; // welcome page height triggerParms["dhtmlURL"]=3D "/medlineplus/images/FSRInvite.html"; // ****************************** // * stdLauncher.js * // ****************************** // Customer: National Library of Medicine // Version : DHTML Trigger 2.4 var popUpURL =3D "//www.foreseeresults.com/survey/display"; // base URL = to the survey=20 var FSRImgURL =3D "//www.foreseeresults.com/survey/FSRImg"; var ckAlreadyShown =3D triggerParms["ascookie"]; // name of the = persistent/session cookie var ckLoyaltyCount =3D triggerParms["lfcookie"]; // name of the loyalty = count cookie var fullURL=3Dnull; var oldURL=3Dnull; var fsr_browser =3Dnull; var myPopUp=3Dnull; var winOptions =3D "width=3D 1,height=3D 1,top=3D 4000,left=3D = 4000,resizable=3Dyes,scrollbars=3Dyes"; var persistentExpires =3D new Date(); // persistent cookie expiration=20 persistentExpires.setTime(persistentExpires.getTime() + = (triggerParms["rw"]*60*1000)); function ForeCStdGetCookie (name) { var arg =3D name + "=3D"; var alen =3D arg.length; var clen =3D document.cookie.length; var i =3D 0; while (i < clen) { var j =3D i + alen; if (document.cookie.substring(i, j) =3D=3D arg) { return ForeCStdGetCookieVal (j); } i =3D document.cookie.indexOf(" ", i) + 1; if (i =3D=3D 0) { break; } } return null; } function fsr_IEshowWindow() { if(myPopUp !=3D null && !myPopUp.closed) {return;} if (eval("document.all.fsr_window").filters.revealTrans.status =3D=3D = 0) { eval("document.all.fsr_window").filters.revealTrans.transition =3D 23 = ; eval("document.all.fsr_window").filters.revealTrans.Apply(); eval("document.all.fsr_window").style.visibility =3D 'visible'; eval("document.all.fsr_window").filters.revealTrans.Play(); } else { eval("document.all.fsr_window").style.visibility =3D 'visible'; } } function fsr_hideWindow() { if (fsr_browser=3D=3D"fsr_ie"){ if (eval("document.all.fsr_window").filters.revealTrans.status =3D=3D = 0) { eval("document.all.fsr_window").filters.revealTrans.transition =3D = 23; eval("document.all.fsr_window").filters.revealTrans.Apply(); eval("document.all.fsr_window").style.visibility =3D 'hidden'; eval("document.all.fsr_window").filters.revealTrans.Play(); } else { eval("document.all.fsr_window").style.visibility =3D 'hidden'; } } else { document.getElementById("fsr_window").style.visibility =3D 'hidden'; } } function fsr_showWindow() { if(myPopUp !=3D null && !myPopUp.closed) {return;} document.getElementById("fsr_window").style.visibility =3D 'visible'; } function ForeCStdSetCookie (name, value) { var argv =3D ForeCStdSetCookie.arguments; var argc =3D ForeCStdSetCookie.arguments.length; var expires =3D (argc > 2) ? argv[2] : null; var path =3D (argc > 3) ? argv[3] : null; var domain =3D (argc > 4) ? argv[4] : null; var secure =3D (argc > 5) ? argv[5] : false; document.cookie =3D name + "=3D" + escape (value) + ((expires =3D=3D null) ? "" : ("; expires=3D" + expires.toGMTString())) = + ((path =3D=3D null) ? "" : ("; path=3D" + path)) + ((domain =3D=3D null) ? "" : ("; domain=3D" + domain)) + ((secure =3D=3D true) ? "; secure" : ""); } function ForeCStdGetCookieVal(offset) { var endstr =3D document.cookie.indexOf (";", offset); if (endstr =3D=3D -1) { endstr =3D document.cookie.length; } return unescape(document.cookie.substring(offset, endstr)); } function specialEscape(str) { var translated =3D ""; var i;=20 var found =3D 0; for(i =3D 0; (found =3D str.indexOf('+', found)) !=3D -1; ) { translated +=3D str.substring(i, found) + "%2B"; i =3D found + 1; found++; } translated +=3D str.substring(i, str.length); return translated; } function Pop(){ myPopUp =3D window.open(fullURL, 'survey',winOptions); if ( myPopUp!=3Dnull && !myPopUp.closed) { if (triggerParms["pu"] =3D=3D 1){ self.focus(); } else { myPopUp.focus(); =09 } } } function checkMAC(){ if(navigator.platform.indexOf("Win32") >=3D 0){ return false; } else { return true; }=09 } function currentLocationExcluded() {=09 var parentURLPath =3D window.location.pathname;//location path for(key in excludeList) { if(parentURLPath.indexOf(excludeList[key]) !=3D -1) { return true; } } return false; } var FSRImg; var surveyProcessCont =3D 1; function stdImgProc() { if (fsr_browser =3D=3D "fsr_ie") { if(triggerParms["compliant508"] =3D=3D 1) { fsr_IEshowWindow(); } else { fsr_IEshowWindow(); } } else { if(triggerParms["compliant508"] =3D=3D 1) { fsr_showWindow();} else { setTimeout ( "fsr_showWindow();", 2000, "JavaScript" ); } } } function imgOnloadProc() { if(surveyProcessCont =3D=3D 1 && FSRImg.width =3D=3D 3) { stdImgProc(); = } return true; } function imgErrorProc() { surveyProcessCont =3D 0; return true; } function Poll() {=20 if(triggerParms["dt"] =3D=3D 1) { return; } if(currentLocationExcluded()) { return; } var stickyCounter =3D ForeCStdGetCookie(ckLoyaltyCount); // check = counter cookie var alreadyShown =3D ForeCStdGetCookie(ckAlreadyShown); // check if we = already have shown survey var pageCount; var randNum =3D Math.random(); randNum *=3D 100; if (stickyCounter =3D=3D null) { pageCount =3D 1;=20 ForeCStdSetCookie(ckLoyaltyCount, pageCount, = null,'/',triggerParms["domain"]); stickyCounter =3D ForeCStdGetCookie(ckLoyaltyCount); } if (stickyCounter !=3D null) { pageCount =3D stickyCounter; if(pageCount >=3D triggerParms["lf"]) { if(alreadyShown =3D=3D null) { if (triggerParms["rso"] =3D=3D 1 && triggerParms["aro"] =3D=3D 1) { triggerParms["sp"] =3D 100.0; // Update Ssample percentage } if(randNum <=3D triggerParms["sp"]) { var fsr_mac=3D checkMAC(); fsr_browser=3D"fsr_nn6"; if(document.all){=20 fsr_browser =3D "fsr_ie"; } if(document.layers) { fsr_browser =3D "fsr_nn"; } fullURL =3D popUpURL + "?" + "width=3D" + triggerParms["width"] + "&height=3D" + triggerParms["height"] + "&cid=3D" + specialEscape(escape(triggerParms["cid"])) + "&mid=3D" = + specialEscape(escape(triggerParms["mid"])); if ((triggerParms["omb"] ) !=3D null) { fullURL +=3D "&omb=3D" + escape(triggerParms["omb"]); } if ((triggerParms["cmetrics"] ) !=3D null) { fullURL +=3D "&cmetrics=3D" + escape(triggerParms["cmetrics"]); } if (triggerParms["olpu"] =3D=3D 1) { fullURL +=3D "&olpu=3D1"; } if ((triggerParms["dcUniqueId"]) !=3D null) { fullURL +=3D "&dcUniqueId=3D" + = escape(triggerParms["dcUniqueId"]); } if (triggerParms["rso"] =3D=3D 1) { fullURL +=3D "&rso=3D1&rct=3D" + triggerParms["rct"] + "&rds=3D" + = triggerParms["rds"] + "&mrd=3D" + triggerParms["mrd"] + "&rws=3D" + = triggerParms["rw"]; } if (triggerParms["capturePageView"] =3D=3D 1) { triggerParms["cpp_3"] =3D "PageView:"+ pageCount; // customer = parameter 3 - Page View } var dcQString =3D ""; if ((triggerParms["midexp"] ) !=3D null) { fullURL +=3D "&ndc=3D1&fsexp=3D5256000&midexp=3D" + = triggerParms["midexp"]; dcQString =3D "ndc=3D1&midexp=3D" + triggerParms["midexp"] + = "&mid=3D" + specialEscape(escape(triggerParms["mid"])); if(triggerParms["dcUniqueId"]!=3Dnull) { dcQString +=3D = "&dcUniqueId=3D" + specialEscape(escape(triggerParms["dcUniqueId"])); } } var customerParams =3D ""; for(paramKey in triggerParms) { if(paramKey.substring(0,3) =3D=3D "cpp"){ fullURL +=3D "&" + paramKey + "=3D" + = escape(triggerParms[paramKey]); } }=09 oldURL=3DfullURL; fullURL+=3D "&cpp_4=3D" + escape("popupStats:window=3Dnormal = browser=3D"+fsr_browser+" mac=3D"+ fsr_mac); if (triggerParms["rso"] !=3D 1) { if(triggerParms["npc"] =3D=3D 1) { ForeCStdSetCookie(ckAlreadyShown, = 'true',null,'/',triggerParms["domain"]); } else { ForeCStdSetCookie(ckAlreadyShown, 'true', = persistentExpires,'/',triggerParms["domain"]); } } myPopUp =3D window.open(fullURL, 'survey',winOptions); if (myPopUp !=3D null && !myPopUp.closed && (triggerParms["dhtml"] = =3D=3D 0)) { if (triggerParms["pu"] =3D=3D 1){ self.focus(); } else { myPopUp.focus(); //focusing on survey window =09 } } else { =09 if (fsr_mac=3D=3Dfalse && (fsr_browser !=3D "fsr_nn") && = (triggerParms["dhtml"] =3D=3D 1)) { fullURL=3DoldURL; fullURL+=3D "&cpp_4=3D" + escape("popupStats:window=3Ddhtml = browser=3D"+fsr_browser+" mac=3D"+ fsr_mac); fsr_sw =3D screen.width; fsr_sh =3D screen.height; fsr_left =3D (fsr_sw -triggerParms["dhtmlWidth"])/2; fsr_top =3DMath.min((fsr_sh - = triggerParms["dhtmlHeight"])/2,150); =09 document.write("<div id=3D\"fsr_window\" = style=3D\"position:absolute; left:" + fsr_left+"px; top:"+fsr_top + "px; z-index:1; border:0; visibility:hidden; = filter:revealTrans(Duration=3D0.5, Transition=3D23);\">" + "<iframe id=3D\"cframe\" src=3D"+"\""+ = triggerParms["dhtmlURL"]+"?fullURL=3D"+fullURL+"\" = width=3D"+triggerParms["dhtmlWidth"]+" = height=3D"+triggerParms["dhtmlHeight"]+"></iframe></div>"); =09 if(dcQString =3D=3D "") { stdImgProc(); } else { FSRImg =3D new Image(); FSRImg.src =3D null; FSRImg.onerror =3D imgErrorProc; FSRImg.onload =3D imgOnloadProc; FSRImg.src =3D FSRImgURL + "?" + dcQString; } } } } } }=09 pageCount++; ForeCStdSetCookie(ckLoyaltyCount, pageCount, = null,'/',triggerParms["domain"]); =09 } } Poll();=0A= ------=_NextPart_000_0000_01C8A455.04DC48E0--