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July 23, 2008

A new study published today in by the Human Reproduction Journal
has once again linked consumption of soy with reduced sperm count.

The study, found that eating as little as half a cup of soy a day can cut
your perm count in half. Soy foods contain substances called
"isoflavones" which are believed to cause sperm death.

The normal concentration of sperm for fertile men is 120 million sperm
per milliliter. Men who ate the highest concentrations of soy in the
study were found to have sperm concentrations of only 41 million. By
comparison, men with sperm concentrations of 20 million or less are
considered infertile.

The study, which was conducted by researchers affiliated with the
Harvard School of Public Health and Massachusetts General Hospital
and Brigham and Women's Hospital, is likely to continue to fuel the
raging debate in scientific circles over the effect of soy on male fertility.

Previous studies which established the adverse link between soy
consumption and sperm count were attacked by soy growers who
pointed out that in Asian societies men eat far more soy in their daily
diets can have no problems with fertility.

Soy is growing in popularity in American, European and other Western
diets, and can be found in a wide range of products including meatless
burgers (soy burgers), tofu products and is used widely in Chinese and
Asian cooking.

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Source:

Hum. Reprod. Advance Access published online on July 23, 2008
Human Reproduction, doi:10.1093/humrep/den243

© The Author 2008. Published by Oxford University Press on behalf of the European
Society of Human Reproduction and Embryology. All rights reserved.

Soy food and isoflavone intake in relation to semen quality parameters among men
from an infertility clinic
Jorge E. Chavarro1,2,7, Thomas L. Toth3, Sonita M. Sadio4 and Russ Hauser3,5,6
1 Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave.,
Boston, MA, USA 2 Channing Laboratory, Department of Medicine, Brigham and
Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA 3 Vincent
Memorial Obstetrics and Gynecology Service, Massachusetts General Hospital and
Harvard Medical School, Boston, MA, USA 4 Department of Urology, Massachusetts
General Hospital and Harvard Medical School, Boston, MA, USA 5 Department of
Environmental Health, Harvard School of Public Health, Boston, MA, USA 6
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA

STUDYBACKGROUND: High isoflavone intake has been related to decreased fertility
in animal studies, but data in humans are scarce. Thus, we examined the association
of soy foods and isoflavones intake with semen quality parameters.

METHODS: The intake of 15 soy-based foods in the previous 3 months was assessed
for 99 male partners of subfertile couples who presented for semen analyses to the
Massachusetts General Hospital Fertility Center. Linear and quantile regression were
used to determine the association of soy foods and isoflavones intake with semen
quality parameters while adjusting for personal characteristics.

RESULTS: There was an inverse association between soy food intake and sperm
concentration that remained significant after accounting for age, abstinence time,
body mass index, caffeine and alcohol intake and smoking. In the multivariate-
adjusted analyses, men in the highest category of soy food intake had 41 million
sperm/ml less than men who did not consume soy foods (95% confidence interval =
–74, –8; P, trend = 0.02). Results for individual soy isoflavones were similar to the
results for soy foods and were strongest for glycitein, but did not reach statistical
significance. The inverse relation between soy food intake and sperm concentration
was more pronounced in the high end of the distribution (90th and 75th percentile)
and among overweight or obese men. Soy food and soy isoflavone intake were
unrelated to sperm motility, sperm morphology or ejaculate volume.

CONCLUSIONS: These data suggest that higher intake of soy foods and soy
isoflavones is associated with lower sperm concentration.
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